Description: Neural Control of Renal Function, Hardcover by Kopp, Ulla C.; Granger, D. Neil (EDT); Granger, Joey P. (EDT), ISBN 1615047778, ISBN-13 9781615047772, Brand New, Free shipping in the US The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of a1-adrenoceptors and increase renin secretion rate by activation of ß1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Under normal conditions, the renal mechanosensory nerves activated by stretch of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension.
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Book Title: Neural Control of Renal Function
Number of Pages: 106 Pages
Language: English
Publication Name: Neural Control of Renal Function
Publisher: Morgan & Claypool Publishers
Publication Year: 2018
Item Height: 0.3 in
Subject: Nephrology, Life Sciences / Anatomy & Physiology (See Also Life Sciences / Human Anatomy & Physiology), Life Sciences / General, Life Sciences / Human Anatomy & Physiology
Features: New Edition
Type: Textbook
Item Weight: 15.1 Oz
Item Length: 9.2 in
Subject Area: Science, Medical
Author: D. Neil Granger, Ulla C. Kopp, Joey P. Granger
Series: Colloquium Series on Integrated Systems Physiology: from Molecule to Function to Disease Ser.
Item Width: 7.5 in
Format: Hardcover
