Serotonin and Anxiety: Neuroanatomical, Pharmacological, and Functional Aspects

Description: Serotonin and Anxiety by Caio Maximino This study of the areas of the brain linked to defensive behavior deploys a unique integrative analysis that explores the neural hierarchy of cerebral structures that control anxiety and fear. It adopts the revealing perspective of systems neuroscience. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin – the neurotransmitter which has probably most captured the imagination of laymen and academics alike – is as elusive as the clinical aspects of serotonergic medications. Why are drugs acting at certain serotonin receptors efficacious against generalized anxiety disorder, but not panic disorder? Why is the inverse true for monoamine oxidase inhibitors? These clinically relevant issues are clarified by the neurochemical, anatomical and physiological organization of the serotonergic system.In this book, the author summarizes the latest findings regarding the role of serotonin in modulating the activity of brain regions which organize behavioral patterns associated with fear, anxiety and stress. The emergent picture is one of far greater complexity than previously thought: while the serotonergic innervation of those brain regions arises from the same structure – the dorsal raphe nucleus – that structure is not homogeneous from anatomical, physiological and neurochemical points of view, nor are its projections to the cerebral aversive and behavioral inhibition systems.The diverse findings which compose this picture of complexity – whether they arise from developmental neurobiology, electrophysiology, neurochemistry, neuroendocrinology, neuropsychopharmacology or behavioral neuroscience – are integrated in this book. Advanced undergraduate, graduate students, and researchers will benefit from the information. The result sheds light on many important questions regarding the neuroanatomical, pharmacological and functional aspects of the role of serotonin in anxiety disorders, and points to future avenues of research. Notes A unique, integrated approach to the organization of brain structures that play a part in defensive behaviorFocuses on animal researchPresents interpretations of behavioral, pharmacological, neuroanatomical, and electrophysiological findings¿ Back Cover Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin - the neurotransmitter which has probably most captured the imagination of laymen and academics alike - is as elusive as the clinical aspects of serotonergic medications. Why are drugs acting at certain serotonin receptors efficacious against generalized anxiety disorder, but not panic disorder? Why is the inverse true for monoamine oxidase inhibitors? These clinically relevant issues are clarified by the neurochemical, anatomical and physiological organization of the serotonergic system. In this book, the author summarizes the latest findings regarding the role of serotonin in modulating the activity of brain regions which organize behavioral patterns associated with fear, anxiety and stress. The emergent picture is one of far greater complexity than previously thought: while the serotonergic innervation of those brain regions arises from the same structure - the dorsal raphe nucleus - that structure is not homogeneous from anatomical, physiological and neurochemical points of view, nor are its projections to the cerebral aversive and behavioral inhibition systems. The diverse findings which compose this picture of complexity - whether they arise from developmental neurobiology, electrophysiology, neurochemistry, neuroendocrinology, neuropsychopharmacology or behavioral neuroscience - are integrated in this book. Advanced undergraduate, graduate students, and researchers will benefit from the information. The result sheds light on many important questions regarding the neuroanatomical, pharmacological and functional aspects of the role of serotonin in anxiety disorders, and points to future avenues of research. Table of Contents Introduction and scope of the review.- Anxiety and risk assessment.- Fear/panic and the fight/flight/freeze system.- "Coping" styles, stress reactivity, and the active-passive continuum.- Serotonin in the nervous system of vertebrates.- Synthesis and metabolism of serotonin.- Transport of serotonin: SERT and uptake.- Serotonin receptors.- 5-HT1A receptors.- 5-HT1B receptors.- 5-HT2C receptors.- Nodal structures in anxiety-like and panic-like responses.- Nodal structures regulating anxiety: The behavioral inhibition system.- "Limbic" portions of the medial prefrontal cortex.- The extended amygdala.- The ventral hippocampus.- The lateral habenula.- Nodal structures regulating panic: The cerebral aversive system.- The central amygdala.- The medial hypothalamic defense system.- The mesopontine rostromedial tegmental nucleus.- The periaqueductal gray area.- Locus coeruleus.- The dual role hypothesis.- Destruction or blockade of DRN neurons is anxiolytic and panicogenic.- The defensive context for increased serotonin release.- Topographic organization of DRN. - The dorsal portion of the DRN is part of a mesocorticolimbic system involved in anxiety-like responses.- The caudal portion of the DRN is highly responsive to stress-related peptides.- The lateral wings of the DRN are involved in panic-like responses.- General conclusions. Review From the reviews:"This is a concise, information-packed, to-the-point book on the neurobiology of serotonin in anxiety. … Researchers studying anxiety and the role of serotonin might find this useful. … Each chapter is referenced with relevant and timely citations from the scientific literature." (Michael Joel Schrift, Doodys Review Service, November, 2012) Review Quote From the reviews:This is a concise, information-packed, to-the-point book on the neurobiology of serotonin in anxiety. … Researchers studying anxiety and the role of serotonin might find this useful. … Each chapter is referenced with relevant and timely citations from the scientific literature. (Michael Joel Schrift, Doodys Review Service, November, 2012) Feature A unique, integrated approach to the organization of brain structures that play a part in defensive behavior Focuses on animal research Presents interpretations of behavioral, pharmacological, neuroanatomical, and electrophysiological findings Details ISBN1461440475 Author Caio Maximino Publisher Springer-Verlag New York Inc. Year 2012 ISBN-10 1461440475 ISBN-13 9781461440475 Format Paperback Imprint Springer-Verlag New York Inc. Place of Publication New York, NY Country of Publication United States DEWEY 616.8 Short Title SEROTONIN & ANXIETY 2012/E Language English Media Book Series Number 2 Subtitle Neuroanatomical, Pharmacological, and Functional Aspects Publication Date 2012-05-31 Pages 111 Edition 2012th Illustrations 5 Illustrations, color; 2 Illustrations, black and white; X, 111 p. 7 illus., 5 illus. in color. Series SpringerBriefs in Neuroscience DOI 10.1007/978-1-4614-4048-2 AU Release Date 2012-05-31 NZ Release Date 2012-05-31 US Release Date 2012-05-31 UK Release Date 2012-05-31 Edition Description 2012 ed. Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96372225;

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